Cimetidine and surgery.

Cimetidine for ulcers recurring after gastric surgery.

Cimetidine and renal failure.

Introduction Cimetidine is a recently introduced but widely used histamine H2-antagonist. It is known to produce significant increases in plasma creatinine in normal people but the increased values usually remain in the normal range (Burland and Simkins, 1977). In clinical trials a tendency for plasma creatinine to rise, particularly in patients treated with high doses of cimetidine, was found ...

antagonists-cimetidine and ranitidine

Few drugs have so rapidly gained an established place in modern medicine as the histamine H, receptor antagonists. As a result of the inventiveness of James Black and his colleagues, the theoretical concept of a second class of histamine receptors became a therapeutic reality. The failure of classic antihistamine drugs (more appropriately H1 receptor antagonists) to block the actions of histami...

Cimetidine and thrombocytopenia

The control subjects had recently attended the fracture clinic and were otherwise healthy. They were matched with the patients for age (± 5 years), sex, social class, and marital status and were not significantly different from the patients in height or weight distribution. The controls were interviewed about their diet in the same manner as the patients. The statistical significance of differe...

Effects of glycopyrrolate and cimetidine on gastric volume and acidity in patients awaiting surgery.

Glycopyrrolate or cimetidine was administered before operation to patients undergoing elective surgery. After the induction of anaesthesia, the stomach contents were retrieved and the volume and pH measured. Neither drug diminished the volume of gastric contents compared with control. Glycopyrrolate produced little diminution in hydrogen ion concentration. Cimetidine caused a marked increase in...